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Title 

Azuki bean (Vigna angularis) extract inhibits the development of experimentally induced atopic dermatitis-like skin lesions in NC/Nga mice

Authors 

T M CollantesMun Chual RhoKwon Hyung JunB G JungM M AlfajaroD S KimH J KimM HosmilloJ G ParkK Y SonS I ParkM I KangSu-Jin ParkSeung Woong LeeWoo Song LeeK O Cho

Publisher 

Elsevier

Issue Date 

2012

Citation 

Food Chemistry, vol. 132, no. 3, pp. 1269-1275

Keywords 

Atopic dermatitisAzuki beanIgEImmune cellsInflammatory cytokinesNC/Nga mice

Abstract 

The present study investigated the effects of azuki bean (Vigna angularis) extract (VAE) on the progress of atopic dermatitis (AD)-like skin lesions in NC/Nga mice induced by 1-chloro-2,4-dinitrobenzene. The efficacy of VAE in NC/Nga mice was determined by measuring gross and histological skin lesions, serum IgE levels, eosinophil ratio in peripheral leucocytes, and mRNA expression levels of interleukin (IL)-4, tumour necrosis factor (TNF)-α and interferon (IFN)-γ in splenocytes. Continuous ingestion of VAE inhibited the development of the AD-like skin lesions in a dose-dependent manner. In the VAE-treated mice, the numbers of mast cells in the skin, eosinophil ratio in peripheral leucocytes, relative mRNA expression of inflammatory cytokines in the spleen, and serum IgE levels were significantly reduced. Results suggest that VAE can inhibit the development of AD-like skin lesions in NC/Nga mice by regulating immune mediators and cells, and may be an effective alternative therapy for AD.

ISSN 

0308-8146

Link 

http://dx.doi.org/10.1016/j.foodchem.2011.11.100

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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