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Title 

Fibulin-3 promoter methylation alters the invasive behavior of non-small cell lung cancer cell lines via MMP-7 and MMP-2 regulation

Authors 

E J KimS Y LeeM K WooS I ChoiT R KimM J KimK C KimEun Wie ChoI G Kim

Publisher 

Spandidos Publications

Issue Date 

2012

Citation 

International Journal of Oncology, vol. 40, no. 2, pp. 402-408

Keywords 

Fibulin-3InvasionLung cancerMethylationMMP-7Tumour suppressor

Abstract 

Fibulin-3, an extracellular glycoprotein, has been suggested as having functions in tissue regeneration and organogenesis. However, its role in cancer remains unclear. We show here that fibulin-3 was silenced by hypermethylation of the promoter region in the relatively invasive A549 non-small cell lung cancer (NSCLC) cells compared with less invasive H460 NSCLC cells. Enforced expression of fibulin-3 in A549 cells down-regulated cellular MMP-7 and MMP-2, which was followed by inhibition of cell invasiveness. Conversely, suppression of fibulin-3 expression with siRNA in H460 cells showed the opposite effect. These results indicate that fibulin-3 is a negative regulator of invasiveness in NSCLC and further studies are needed for its therapeutic applications in treatment of NSCLC.

ISSN 

1019-6439

Link 

http://dx.doi.org/10.3892/ijo.2011.1191

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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