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Title 

Tissue-specific expression of human calcineurin-binding protein 1 in mouse synovial tissue can suppress inflammatory arthritis

Authors 

D H YuJ K YiS J ParkM O KimH J KimH S YuhK B BaeY R JiH S LeeS G LeeY S ChooJ Y KimD H YoonByung Hwa HyunZ Y Ryoo

Publisher 

Mary Ann Liebert

Issue Date 

2012

Citation 

Journal of Interferon and Cytokine Research, vol. 32, no. 1, pp. 6-11

Abstract 

Calcineurin (CN) is a calcium- and calmodulin-dependent serine/threonine phosphatase. In immune cells, CN controls the activity of a wide range of transcription factors, including nuclear factor of activated T, nuclear factor-kappa B, c-fos, and Elk-1. CN plays an important role in synoviocyte activation and arthritis progression in vivo and this function is tightly linked to dysregulated intracellular Ca 2+ store and Ca 2+ response triggered by proinflammatory cytokines. In the present study, transgenic mice expressing human calcineurin-binding protein 1 (hCabin1) were generated, driven by type II collagen promoter, and the efficiency of these mice was investigated by experimental arthritis. These transgenic mice successfully expressed hCabin1 in joint tissue as well as other organs such as liver, heart, and brain. The overexpression of hCabin1 reduced the disease severity during collagen-induced arthritis. In fibroblast-like synoviocytes (FLSs) from hCabin1 transgenic mice, the productions of these cytokines, including interleukin (IL)-2, IL-4, and IFN-γ, were decreased and matrix metalloproteinases were also depressed in transgenic mice FLS. In addition, these effects were only found in the joint tissue, which is a major inflammation site. These findings will provide a better knowledge of the pathogenic mechanisms of rheumatoid arthritis and a potential animal model of the chronic inflammatory conditions, including atherosclerosis and transplantation.

ISSN 

1079-9907

Link 

http://dx.doi.org/10.1089/jir.2010.0155

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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