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Title 

Flavimycins A and B, dimeric 1,3-dihydroisobenzofurans with peptide deformylase inhibitory activity from Aspergillus flavipes

 

신규 PDF 저해물질, Flavimycins A와 B

Authors 

Yun Ju KwonM J SohnChang-Jin KimH KoshinoWon Gon Kim

Publisher 

American Chemical Society

Issue Date 

2012

Citation 

Journal of Natural Products, vol. 75, no. 2, pp. 271-274

Abstract 

Flavimycins A (1) and B (2), novel dimeric 1,3-dihydroisobenzofurans, were isolated as inhibitors of peptide deformylase from cultures of Aspergillus flavipes. Their chemical structures were established by NMR and MS data analysis. Compounds 1 and 2 exist as epimeric mixtures at C-1 through fast hemiacetal-aldehyde tautomerism. Compounds 1 and 2 inhibited Staphylococcus aureus peptide deformylase with IC 50 values of 35.8 and 100.1 μM, respectively. Consistent with their PDF inhibition, 1 showed two times stronger antibacterial activity than 2 on S. aureus including MRSA, with MIC values of 32-64 μg/mL.

ISSN 

0163-3864

Link 

http://dx.doi.org/10.1021/np200720v

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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