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Title 

Verrulactones A and B, new inhibitors of Staphylococcus aureus enoyl-ACP reductase produced by Penicillium verruculosum F375

 

Penicillium verruculosum이 생산하는 새로운 항세균 enoyl-ACP reductase 저해물질

Authors 

Nyung KimM J SohnChang-Jin KimH J KwonWon Gon Kim

Publisher 

Elsevier

Issue Date 

2012

Citation 

Bioorganic & Medicinal Chemistry Letters, vol. 22, no. 7, pp. 2503-2506

Keywords 

Enoyl-ACP reductaseFabIInhibitorPenicillium verruculosumStaphylococcus aureus

Abstract 

New dimeric compounds of alternariol class, verrulactones A and B, were isolated from a culture broth of the fungal strain Penicillium verruculosum F375 and their structure were established by various spectral analysis. Verrulactones A and B strongly inhibited Staphylococcus aureus enoyl-ACP reductase with IC 50 of 0.92 and 1.41 μM, respectively, and also showed antibacterial activity against S. aureus and MRSA with MICs of 8 and 16 μg/mL, respectively.

ISSN 

0960-894X

Link 

http://dx.doi.org/10.1016/j.bmcl.2012.02.001

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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