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Title 

Anti-allergic effect of lambertianic acid from Thuja orientalis in mouse bone marrow-derived mast cells

Authors 

Hee Sung ChaeYoung Won Chin

Publisher 

Informa Healthcare

Issue Date 

2012

Citation 

Immunopharmacology and Immunotoxicology, vol. 34, no. 2, pp. 250-255

Keywords 

β-hexosaminidaseAllergyBone marrow-derived mast cellCOX-2IL-6Lambertianic acidLTC4PGD2

Abstract 

Lambertianic acid is a bioactive diterpene found in the leaves of Thuja orientalis. Its effect on the bone marrow-derived mast cell (BMMC) mediated allergy and inflammation mechanism remains unknown. In this study, lambertianic acid was evaluated for its effect on the allergicmediators, including prostaglandin D2 (PGD2), leukotriene C4 (LTC4), β-hexosaminidase (β-Hex) and cyclooxygenase-2 (COX-2) protein, in phorbol 12-myristate 13-acetate (PMA) plus calcimycin-stimulated BMMCs. The results revealed that lambertianic acidinhibited the production of interleukin-6 (IL-6), PGD2 and LTC4, the expression of COX-2 and the degranulation of β-hexosaminidase in the PMA plus calcimycin-induced BMMCs. Taken together, these findings implied that lambertianic acid may possess the potential in the treatment of allergy.

ISSN 

0892-3973

Link 

http://dx.doi.org/10.3109/08923973.2011.600763

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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