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Title 

Extracellular protease in Actinomycetes culture supernatants inhibits and detaches Staphylococcus aureus biofilm formation

Authors 

J H ParkJ H LeeChang-Jin KimJae-Chan LeeM H ChoJ Lee

Publisher 

Springer Verlag (Germany)

Issue Date 

2012

Citation 

Biotechnology Letters, vol. 34, no. 4, pp. 655-661

Keywords 

ActinomycetesBiofilmProteaseStaphylococcus aureus

Abstract 

Bacterial biofilms are associated with chronic infections due to their resistance to antimicrobial agents. Staphylococcusaureus is a versatile human pathogen and can form biofilms on human tissues and diverse medical devices. To identify novel biofilm inhibitors of S. aureus, the supernatants from a library of 458 Actinomycetes strains were screened. The culture supernatants (1% v/v) of more than 10 Actinomycetes strains inhibited S. aureus biofilm formation by more than 80% without affecting the growth. The culture supernatants of these biofilm-reducing Actinomycetes strains contained a protease (equivalent to 0. 1 μg proteinase K ml -1), which both inhibited S. aureus biofilm formation and detached pre-existing S. aureus biofilms. This study suggests that protease treatment could be a feasible tool to reduce and eradicate S. aureus biofilms.

ISSN 

0141-5492

Link 

http://dx.doi.org/10.1007/s10529-011-0825-z

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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