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Title 

Zuonin B Inhibits Lipopolysaccharide-Induced Inflammation via Downregulation of the ERK1/2 and JNK Pathways in RAW264.7Macrophages

Authors 

Mee Young LeeJ E YukOk-Kyoung KwonSei Ryang OhHyeong Kyu LeeKyung Seop Ahn

Publisher 

Hindawi Publishing Corporation

Issue Date 

2012

Citation 

Evidence-Based Complementary and Alternative Medicine, vol. 2012, no. 0, pp. 728196-728196

Abstract 

We investigated whether Zuonin B exerts immunological effects on RAW264.7 cells. Zuonin B, isolated from flower buds of Daphne genkwa, suppressed the levels of nitric oxide and prostaglandin E2, as well as proinflammatory cytokines, such as tumor necrosis factor-α and interleukin-(IL-) 6, in lipopolysaccharide-stimulated macrophages. Moreover, the compound inhibited cyclooxygenase-2 and inducible nitric oxide synthase expression. Zuonin B attenuated NF-kappaB (NF-κB) activation via suppressing proteolysis of inhibitor kappa B-alpha (IκB-α) and p65 nuclear translocation as well as phosphorylation of extracellular signal-regulated kinase 1/2 and c-Jun N-terminal kinase. Additionally, IL-4 and IL-13 production in ConA-induced splenocytes was inhibited by Zuonin B. In conclusion, the anti-inflammatory effects of Zuonin B are attributable to the suppression of proinflammatory cytokines and mediators via blockage of NF-κB and AP-1 activation. Based on these findings, we propose that Zuonin B is potentially an effective functional chemical candidate for the prevention of inflammatory diseases.

ISSN 

1741-427X

Link 

http://dx.doi.org/10.1155/2012/728196

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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