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Title 

Tigliane diterpene esters with IFN γ-inducing activity from the leaves of Aleurites fordii

Authors 

Y H PeiJae Wha KimHo Bum KangHyeong Kyu LeeC S KimHyuk Hwan SongY W ChinSei Ryang Oh

Publisher 

Elsevier

Issue Date 

2012

Citation 

Bioorganic & Medicinal Chemistry Letters, vol. 22, no. 6, pp. 2318-2320

Keywords 

Aleurites fordiiEuphorbiaceaeIFN-γ productionPhorbolTigliane diterpene

Abstract 

Bioactivity-guided fractionation on the leaves of Aleurites fordii led to the isolation of a new tigliane diterpene ester, 12-O-hexadecanoyl-7-oxo-5-ene- 16-hydroxyphorbol-13-acetate (1) along with four known compounds, 12-O-hexadecanoyl-7-oxo-5-ene-phorbol-13-acetate (2), 12-O-hexadecanoyl-phorbol- 13-acetate (3), 12-O-hexadecanoyl-16-hydroxyphorbol-13-acetate (4), and 12-O-hexadecanoyl-4-deoxy-4α-16-hydroxyphorbol-13-acetate (5). The structures of these compounds were determined by interpretation of NMR (1D and 2D) spectroscopic data and MS data. All the isolates were evaluated for their effects on the induction of IFN-γ in NK92 cells. Compounds 3 and 4 exhibited the most potent responses in IFN-γ induction, comparable to the positive control, phorbol 12-myristate 13-acetate (PMA).

ISSN 

0960-894X

Link 

http://dx.doi.org/10.1016/j.bmcl.2012.01.057

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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