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Title 

Ethanol extract of Elaeocarpus petiolatus inhibits lipopolysaccharide-induced inflammation in macrophage cells

 

엘리오카퍼스 페티오라투스의 LPS-유도 염증억제

Authors 

Ok-Kyoung KwonKyung Seop AhnJi Won ParkHa young JangHyouk JoungHyeong Kyu LeeSei Ryang Oh

Publisher 

Springer Verlag (Germany)

Issue Date 

2012

Citation 

Inflammation, vol. 35, no. 2, pp. 535-544

Keywords 

COX-2Elaeocarpus petiolatusinflammationMAPKNF-kappaB

Abstract 

Elaeocarpus petiolatus is known to exert active oxygen scavenging, anti-aging, and whitening actions. However, the biological effects of E. petiolatus on inflammation and the underlying mechanisms are yet to be established. In the present study, we investigated the anti-inflammatory effects of the ethanol extract from E. petiolatus (EPE) bark in murine Raw264.7 macrophages stimulated with lipopolysaccharide (LPS). EPE inhibited the production of PGE2, TNF-α, and IL-1β in a dose-dependent manner in Raw264.7 cells stimulated with LPS. The decrease in PGE2 production was correlated with reduced COX-2 expression. Furthermore, EPE suppressed the phosphorylation of extracellular signal-related kinases (ERK), c-Jun N-terminal kinase (JNK), and p38 as well as translocation of the NF-κB p65 subunit from the cytosol to nucleus. Our results suggest that EPE exerts anti-inflammatory activity through inhibition of inflammatory mediators, such as PGE2, TNF-α, and IL-1β, and downregulation of COX-2 via suppression of NF-κB translocation and phosphorylation of ERK, JNK, and p38 in LPS-stimulated Raw264.7 cells.

ISSN 

0360-3997

Link 

http://dx.doi.org/10.1007/s10753-011-9343-3

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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