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Title 

Convenient synthesis of an isoxazole compound, KRIBB3, as an anticancer agent

Authors 

Hyeong Kyu LeeEun Ju YunJi Hye MinKab Seog YoonDong-Ho ChoungSangku Lee

Publisher 

Taylor & Francis

Issue Date 

2012

Citation 

Synthetic Communications, vol. 42, no. 13, pp. 1890-1894

Keywords 

Anticancerantimigratorycyclizationisoxazole

Abstract 

A diaryl isoxazole compound, KRIBB3, which exhibits strong antimigratory and antimitotic activities against cancer cells, was prepared in a practical synthetic way. The synthetic method may provide easy access to KRIBB3 analogs with various substituents at an aryl moiety for structure-activity relationships (SAR), as well as a large quantity of KRIBB3 for in vivo studies.

ISSN 

0039-7911

Link 

http://dx.doi.org/10.1080/00397911.2010.546551

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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