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Title 

Induction of type I interferon by high-molecular poly-γ-glutamate protects B6.A2G-Mx1 mice against influenza A virus

Authors 

H J MoonJ S LeeY K ChoiJ Y ParkM R TalactacM Y E ChowdhuryHaryoung PooM H SungJ H LeeJ U JungC J Kim

Publisher 

Elsevier

Issue Date 

2012

Citation 

Antiviral Research, vol. 94, no. 1, pp. 98-102

Keywords 

B6.A2G-Mx1 mouseHigh-molecular-weight poly-γ-glutamateInfluenza A virusInterferon type IMyxovirus resistance protein

Abstract 

In addition to development of vaccines and synthetic antiviral drugs, recent studies have advocated the use of natural substances that inhibit or prevent viral infections. High-molecular-weight poly-γ-glutamate (HM-γ-PGA) produced by Bacillus subtilis chungkookjang was evaluated for anti-influenza virus activity. HM-γ-PGA induced type I interferons (IFNs), which in turn stimulated expression of Myxovirus resistant 1 protein and IFN-related proteins in vitro. In the B6.A2G- Mx1 mouse model, which mimics the innate immune system of humans, treatment with HM-γ-PGA enhanced the antiviral state of mice and protected them against highly pathogenic influenza A virus. Naturally synthesized HM-γ-PGA has potent anti-influenza activity and may be a useful means for control of influenza virus.

ISSN 

0166-3542

Link 

http://dx.doi.org/10.1016/j.antiviral.2012.02.010

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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