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Title 

Combined analysis of AFP and HCCR-1 as an useful serological marker for small hepatocellular carcinoma: A prospective cohort study

Authors 

G ZhangS A HaH K KimJ YooS KimY S LeeS Y HurY W KimT E KimY G ParkJ WangY YangZ XuEun Young SongZ HuangP JirunJ ZhongtianQ ShishiC ZhuqingqingG LeiJ W Kim

Publisher 

IOS Press

Issue Date 

2012

Citation 

Disease Markers, vol. 32, no. 4, pp. 265-271

Keywords 

AFPbiomarkerHCCR-1Hepatocellular carcinoma

Abstract 

Hepatocellular carcinoma (HCC) is one of the most frequent malignant tumors in the world. The only serological marker widely used for the diagnosis of HCC is alpha-fetoprotein (AFP). Despite that AFP is widely used for the diagnosis of HCC, it has a limit as a serological marker due to its low sensitivity and specificity. The human cervical cancer proto-oncogene 1 (HCCR-1) was previously reported as a new biomarker for HCC. To further evaluate the HCCR-1 as a biomarker for HCC, we conducted the prospective cohort study. We evaluated the significance of simultaneous measurement of 2 tumor markers in the diagnosis of HCC in China, Japan and Korea. Two markers for HCC, AFP and HCCR-1, were measured in the sera obtained from 1,338 patients at the time of initial diagnosis of HCC. Of the 1338 HCC patients, 616 (46%) and 686 (51.3%) were sero-positive for AFP and HCCR-1, respectively. The positive rate for HCC was increased up to 74.1% in combined use of AFP and HCCR-1. Many cases (54%) for AFP-negative HCC were positive for HCCR-1 and vice versa. More importantly, the diagnostic rate for small HCC (< 2 cm) was significantly improved in the combined analysis of AFP and HCCR-1 to 56.9% although it was only 40.1% and 23.4% in the single analysis of HCCR-1 and AFP, respectively. Our result suggests that the HCCR-1 could be an useful biomarker for HCC while the diagnostic rate could be significantly improved in the combined use of HCCR-1 and AFP.

ISSN 

0278-0240

Link 

http://dx.doi.org/10.3233/DMA-2011-0878

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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