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Title 

Homoisoflavonoids from Caesalpinia sappan displaying viral neuraminidases inhibition

 

소목으로부터 분리한 homoisoflavonoids의 viral neuraminidases 저해활성

Authors 

Hyung Jae JungYoung Min KimJang Hoon KimJ Y KimJi Young ParkSu-Jin ParkYoung Bae RyuWoo Song Lee

Publisher 

Pharmaceutical Society of Japan

Issue Date 

2012

Citation 

Biological & Pharmaceutical Bulletin, vol. 35, no. 5, pp. 786-790

Keywords 

α,β-unsaturated carbonylCaesalpinia sappanHomoisoflavonoidNeuraminidase

Abstract 

In this study, twelve neuraminidase (NA) inhibitory compounds 1-12 were isolated from heartwood of Caesalpinia sappan on the basis of their biological activities against three types of viral NAs. Of isolated homoisoflavonoids, sappanone A (2) showed the most potent NAs inhibitory activities with IC 50 values of 0.7 μM [H1N1], 1.1 μM [H3N2], and 1.0 μM [H9N2], respectively, whereas saturated homoisoflavonoid (3) did not show significantly inhibition. This result revealed that α,β-unsaturated carbonyl group in A-ring was the key requirements for viral NAs inhibitory activity. In our enzyme kinetic study, all NA inhibitors screened were found to be reversible noncompetitive types.

ISSN 

0918-6158

Link 

http://dx.doi.org/10.1248/bpb.35.786

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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