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Title | Homoisoflavonoids from Caesalpinia sappan displaying viral neuraminidases inhibition |
| 소목으로부터 분리한 homoisoflavonoids의 viral neuraminidases 저해활성 |
Authors | Hyung Jae Jung; Young Min Kim; Jang Hoon Kim; J Y Kim; Ji Young Park; Su-Jin Park; Young Bae Ryu; Woo Song Lee |
Publisher | Pharmaceutical Society of Japan |
Issue Date | 2012 |
Citation | Biological & Pharmaceutical Bulletin, vol. 35, no. 5, pp. 786-790 |
Keywords | α,β-unsaturated carbonyl; Caesalpinia sappan; Homoisoflavonoid; Neuraminidase |
Abstract | In this study, twelve neuraminidase (NA) inhibitory compounds 1-12 were isolated from heartwood of Caesalpinia sappan on the basis of their biological activities against three types of viral NAs. Of isolated homoisoflavonoids, sappanone A (2) showed the most potent NAs inhibitory activities with IC 50 values of 0.7 μM [H1N1], 1.1 μM [H3N2], and 1.0 μM [H9N2], respectively, whereas saturated homoisoflavonoid (3) did not show significantly inhibition. This result revealed that α,β-unsaturated carbonyl group in A-ring was the key requirements for viral NAs inhibitory activity. In our enzyme kinetic study, all NA inhibitors screened were found to be reversible noncompetitive types. |
ISSN | 0918-6158 |
Link | |
Appears in Collections | |
Registered Date |
2019-05-02 |
| Files in This Item: | Size | Format | |
|---|---|---|---|
| 10726.pdf | 606Kb | Adobe PDF | 
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