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Title 

Upregulation and secretion of kallikrein-related peptidase 6 (KLK6) in gastric cancer

Authors 

J J KimJong Tae KimH R YoonMin Ah KangJ H KimY H LeeJae Wha KimSeon-Jin LeeEun Young SongP K MyungHee Gu Lee

Publisher 

Springer Verlag (Germany)

Issue Date 

2012

Citation 

Tumor Biology, vol. 33, no. 3, pp. 731-738

Keywords 

Gastric cancerImmunohistochemistryInvasivenessKallikreinKLK6

Abstract 

KLK6 encoding kallikrein-related peptidase 6, a trypsin-like serine protease, has been shown to be upregulated in several cancers, although the tumorigenic role of KLK6 has not been elucidated. In this study, KLK6 was identified as a highly upregulated gene in gastric cancer; therefore, the possibility that KLK6 might be a suitable candidate tumor marker was examined. RT-PCR and immunohistochemical analysis showed overexpression of KLK6 in gastric cancer tissues compared to nontumor regions. Sera from gastric cancer patients had a 1.7-fold increase in KLK6 (373.1 μg/L, P=0.048) compared to healthy individuals (214.2 μg/L), although there was no significant difference among patients with various tumor stages. Cellular invasiveness decreased by 45% in cells transfected with KLK6-specific small interfering RNA. Exogenous overexpression of KLK6 led to decreased activity of the E-cadherin promoter. This study shows that KLK6 is significantly upregulated and secreted in gastric cancer tissues and sera, suggesting that KLK6 might be used as a potential biomarker and therapeutic target for gastric cancer.

ISSN 

1010-4283

Link 

http://dx.doi.org/10.1007/s13277-011-0267-1

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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