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Title 

Inhibitory effect of melanogenesis by 5-pentyl-2-furaldehyde isolated from Clitocybe sp.

Authors 

Y H KimSoo-Jin ChooIn Ja RyooBo Yeon KimJong Seog AhnIck-Dong Yoo

Publisher 

The Korean Society for Applied Microbiology

Issue Date 

2012

Citation 

Journal of Microbiology and Biotechnology, vol. 22, no. 6, pp. 814-817

Keywords 

5-penty 1-2-furaldehydeB16F10 melanomaClitocybe spMelanogenesis

Abstract 

In the continued search for melanogenesis inhibitors from microbial metabolites, we found that the culture broth of Clitocybe sp. MKACC 53267 inhibited melanogenesis in B16F10 melanoma cells. The active component was purified by solvent extraction, silica gel chromatography, Sephadex LH-20 column chromatography, and finally by preparative HPLC. Its structure was determined as 5-pentyl-2-furaldehyde on the basis of the UV, NMR, and MS spectroscopic analysis. The 5-pentyl-2-furaldehyde potently inhibited melanogenesis in B16F10 cells with an IC 50 value of 8.4 μg/ml, without cytotoxicity.

ISSN 

1017-7825

Link 

http://dx.doi.org/10.4014/jmb.1101.01053

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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