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Title 

Methanolic extract isolated from root of lycoris aurea inhibits cancer cell growth and endothelial cell tube formation in vitro

Authors 

Moo Rim KangChang Woo LeeJi Eun YunSoo Jin OhS K ParkK LeeH M KimS B HanHyoung-Chin KimJong Soon Kang

Publisher 

The Korean Society of Toxicology

Issue Date 

2012

Citation 

Toxicological Research, vol. 28, no. 1, pp. 33-38

Keywords 

CancerCell cycleGrowthLycoris aureaTube formation

Abstract 

In this study, we investigated the effect of methanolic extract isolated from the root of Lycoris aurea (LA) on the growth of cancer cells and the tube formation activity of endothelial cells. Various cancer cells were treated with LA at doses of 0.3, 1, 3, 10 or 30 μg/ml and LA significantly suppressed the growth of several cancer cell lines, including ACHN, HCT-15, K-562, MCF-7, PC-3 and SK-OV-3, in a dose-dependent manner. We also found that LA induced cell cycle arrest at G2/M phase in ACHN renal cell adenocarcinoma cells. Further study demonstrated that LA concentration-dependently inhibited the tube formation, which is a widely used in vitro model of reorganization stage of angiogenesis, in human umbilical vein endothelial cells. Collectively, these results show that LA inhibits the growth of cancer cells and tube formation of endothelial cells and the growth-inhibitory effect of LA might be mediated, at least in part, by blocking cell cycle progression.

ISSN 

1976-8257

Link 

http://dx.doi.org/10.5487/TR.2012.28.1.033

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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