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Title 

A selective Seoul-Fluor-based bioprobe, SfBP, for vaccinia H1-related phosphatase: a dual-specific protein tyrosine phosphatase

Authors 

Myeong Seon JeongE KimHyo Jin KangE J ChoiA R ChoSang Jeon ChungS B Park

Publisher 

Royal Society of Chemistry

Issue Date 

2012

Citation 

Chemical Communications, vol. 48, no. 52, pp. 6553-6555

Abstract 

We report a Seoul-Fluor-based bioprobe, SfBP, for selective monitoring of protein tyrosine phosphatases (PTPs). A rational design based on the structures at the active site of dual-specific PTPs can enable SfBP to selectively monitor the activity of these PTPs with a 93-fold change in brightness. Moreover, screening results of SfBP against 30 classical PTPs and 35 dual-specific PTPs show that it is selective toward vaccinia H1-related (VHR) phosphatase, a dual-specific PTP (DUSP-3).

ISSN 

1359-7345

Link 

http://dx.doi.org/10.1039/c2cc31377d

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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