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Title 

Ribonuclease E modulation of the bacterial SOS response

 

Ribonuclease E에 의한 박테리아 SOS 감응성의 조절

Authors 

R ManasherobC MillerKwang-Sun KimS N Cohen

Publisher 

Public Library of Science

Issue Date 

2012

Citation 

Plos One, vol. 7, no. 6, pp. e38426-e38426

Abstract 

Plants, animals, bacteria, and Archaea all have evolved mechanisms to cope with environmental or cellular stress. Bacterial cells respond to the stress of DNA damage by activation of the SOS response, the canonical RecA/LexA-dependent signal transduction pathway that transcriptionally derepresses a multiplicity of genes-leading to transient arrest of cell division and initiation of DNA repair. Here we report the previously unsuspected role of E. coli endoribonuclease RNase E in regulation of the SOS response. We show that RNase E deletion or inactivation of temperature-sensitive RNase E protein precludes normal initiation of SOS. The ability of RNase E to regulate SOS is dynamic, as down regulation of RNase E following DNA damage by mitomycin C resulted in SOS termination and restoration of RNase E function leads to resumption of a previously aborted response. Overexpression of the RraA protein, which binds to the C-terminal region of RNase E and modulates the actions of degradosomes, recapitulated the effects of RNase E deficiency. Possible mechanisms for RNase E effects on SOS are discussed.

ISSN 

1932-6203

Link 

http://dx.doi.org/10.1371/journal.pone.0038426

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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