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Title 

Is apparent diffusion coefficient reliable and accurate for monitoring effects of antiangiogenic treatment in a longitudinal study?

Authors 

J Y SuhG ChoY SongC K LeeJong Soon KangM R KangS B ParkY R KimJ K Kim

Publisher 

Wiley-Blackwell

Issue Date 

2012

Citation 

Journal of Magnetic Resonance Imaging, vol. 35, no. 6, pp. 1430-1436

Keywords 

angiogenesisdiffusion magnetic resonance imaginginhibitorsoutcometreatment --------------------------------------------------------------------------------

Abstract 

Purpose: To evaluate the reliability and accuracy of the apparent diffusion coefficient (ADC) for monitoring antiangiogenic treatment in a longitudinal study. Materials and Methods: Tumor volume and ADC were monitored by T2-weighted magnetic resonance imaging (MRI) and diffusion-weighted MRI, respectively, in 18 mice with angiogenesis-dependent tumors (U118MG) before (day 0) and after 2, 7, 14, and 21 days of administration of the antiangiogenic agent sunitinib maleate (n = 12) or vehicle (n = 6). Percent changes in tumor volume and ADC were calculated and correlations between tumor volume and ADC were evaluated. Results: Tumor volume and ADC showed a negative correlation at 69 of the 72 (96%) follow-up measurements. In the 13 mice with tumor regrowth, ADC started to decrease before (27%) or at the same time (73%) as tumor regrowth. Pretreatment ADC and percent change in ADC change on days 0-2 were similar in mice with positive and negative responses to treatment (0.851 vs. 0.999, 24% vs. 16%). Percent change of ADC showed significant negative correlation with percent change in tumor volume in both the control (r = -0.69) and treated (r = -0.65) groups. Conclusion: Percent change in ADC is a reliable and accurate marker for monitoring the effects of antiangiogenic treatment, whereas pretreatment ADC and early changes in ADC (ie, days 0-2) are limited in predicting treatment outcome.

ISSN 

1053-1807

Link 

http://dx.doi.org/10.1002/jmri.23574

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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