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Title 

Pyruvate kinase M2 promotes the growth of gastric cancer cells via regulation of Bcl-xL expression at transcriptional level

Authors 

Oh Hyung KwonT W KangJeong Hwan KimMirang KimS M NohK S SongHyang Sook YooW H KimZ XieD PocalykoSeon-Young KimYong Sung Kim

Publisher 

Elsevier

Issue Date 

2012

Citation 

Biochemical and Biophysical Research Communications, vol. 423, no. 1, pp. 38-44

Keywords 

Bcl-xLGastric cancerNF-κBPKM2

Abstract 

PKM2 is an isoenzyme of the glycolytic enzyme pyruvate kinase that promotes aerobic glycolysis. Here, we describe an important role for PKM2 in regulating the survival of gastric cancer (GC) cells. We showed that PKM2 was overexpressed in gastric tumor tissues compared to normal tissues and its expression level was associated with poor survival of gastric cancer patients. We also showed that PKM2 affected cell survival by regulating Bcl-xL at the transcriptional level. PKM2 knockdown partially affected the stability of NF-kB subunit p65, suggesting that post-translational regulation of p65 by PKM2 is one of plausible mechanisms for the increased cell growth. Therefore, PKM2 may function as an upstream molecule that regulates p65 function and thus enhances the growth of tumor cells.

ISSN 

0006-291X

Link 

http://dx.doi.org/10.1016/j.bbrc.2012.05.063

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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