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Title 

SpiroESTdb: A transcriptome database and online tool for sparganum expressed sequences tags

Authors 

D W KimDong-Wook KimW G YooS H NamM R LeeH W YangJ ParkK LeeS LeeS H ChoW J LeeHong-Seog ParkJ W Ju

Publisher 

BioMed Central

Issue Date 

2012

Citation 

BMC Research Notes, vol. 5, no. 0, pp. 130-130

Keywords 

DatabaseExpressed sequence tags (ESTs)PlerocercoidSparganumSpirometra erinacei

Abstract 

Abstract. Background: Sparganum (plerocercoid of Spirometra erinacei) is a parasite that possesses the remarkable ability to survive by successfully modifying its physiology and morphology to suit various hosts and can be found in various tissues, even the nervous system. However, surprisingly little is known about the molecular function of genes that are expressed during the course of the parasite life cycle. To begin to decipher the molecular processes underlying gene function, we constructed a database of expressed sequence tags (ESTs) generated from sparganum. Findings. SpiroESTdb is a web-based information resource that is built upon the annotation and curation of 5,655 ESTs data. SpiroESTdb provides an integrated platform for expressed sequence data, expression dynamics, functional genes, genetic markers including single nucleotide polymorphisms and tandem repeats, gene ontology and KEGG pathway information. Moreover, SpiroESTdb supports easy access to gene pages, such as (i) curation and query forms, (ii) in silico expression profiling and (iii) BLAST search tools. Comprehensive descriptions of the sparganum content of all sequenced data are available, including summary reports. The contents of SpiroESTdb can be viewed and downloaded from the web (). Conclusions: This integrative web-based database of sequence data, functional annotations and expression profiling data will serve as a useful tool to help understand and expand the characterization of parasitic infections. It can also be used to identify potential industrial drug targets and vaccine candidate genes.

ISSN 

1756-0500

Link 

http://dx.doi.org/10.1186/1756-0500-5-130

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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