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Title 

Identification of novel metastasis suppressor signaling pathways for breast cancer

Authors 

A J MinnE BevilacquaJi Eun YunM R Rosner

Publisher 

Landes Bioscience

Issue Date 

2012

Citation 

Cell Cycle, vol. 11, no. 13, pp. 2452-2457

Keywords 

Breast cancerGene set analysisGene set enrichment analysisGene signatureInvasionMetastasisRaf kinase inhibitory proteinRandom forestsSignaling pathway

Abstract 

Cancer lethality is mainly caused by metastasis. Therefore, understanding the nature of the genes involved in this process has become a priority. Given the heterogeneity of mutations in cancer cells, considerable focus has been directed toward characterizing metastasis genes in the context of relevant signaling pathways rather than treating genes as independent and equal entities. One signaling cascade implicated in the regulation of cell growth, invasion and metastasis is the MAP kinase pathway. Raf kinase inhibitory protein (RKIP) functions as an inhibitor of the MAP kinase pathway and is a metastasis suppressor in different cancer models. By utilizing statistical analysis of clinical data integrated with experimental validation, we recently identified components of the RKIP signaling pathway relevant to breast cancer metastasis. Using the RKIP pathway as an example, we show how prior biological knowledge can be efficiently combined with genome-wide patient data to identify gene regulatory mechanisms that control metastasis.

ISSN 

1538-4101

Link 

http://dx.doi.org/10.4161/cc.20624

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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