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Title 

Soluble expression of OmpA from Haemophilus parasuis in Escherichia coli and its protective effects in the mouse model of infection

Authors 

Jungoh AhnM HongS YooEun Gyo LeeH WonI YoonJoon Ki JungHong-Weon Lee

Publisher 

The Korean Society for Applied Microbiology

Issue Date 

2012

Citation 

Journal of Microbiology and Biotechnology, vol. 22, no. 9, pp. 1307-1309

Keywords 

AntigenEscherichia coliHaemophilus parasuisOmpApelB leader sequenceSoluble expression

Abstract 

Haemophilus parasuis causes contagious porcine Gl?sser's disease leading to severe losses in the swine industry. In this study, we established an efficient Escherichia colibased system for the expression of H. parasuis major outer-membrane protein (MOMP) that has been known as a good vaccine candidate against Gl?sser's disease. Use of an E. coli-derived pelB leader sequence made it possible to produce recombinant MOMP (rMOMP) as the soluble forms without an additional refolding process. Using two different animal models, it was evaluated that the rMOMP was capable of inducing a significant immune response and providing protection against H. parasuis infection.

ISSN 

1017-7825

Link 

http://dx.doi.org/10.4014/jmb.1201.01003

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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