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Title 

Inducible biosynthetic nanoscaffolds as recruitment platforms for detecting molecular target interactions inside living cells

 

세포내 상호작용 감지를 위한 나노 플랫폼

Authors 

S LeeJ S HaSeung Goo LeeT K Kim

Publisher 

American Chemical Society

Issue Date 

2012

Citation 

Journal of American Chemical Society, vol. 134, no. 28, pp. 11346-11349

Abstract 

We present a novel phenotypic readout using inducible, biosynthetic nanoscaffolds to directly visualize dynamic molecular interactions within living cells at the single-cell level with high sensitivity and selectivity. Labeled ferritin is used to form biological nanoparticles inside cells. Specific supramolecular assembly of ferritin-derived nanoparticles induces highly clustered nanoscaffolds. These inducible biosynthetic nanoscaffolds are used as the artificial recruitment/redistribution platform for monitoring interactions of a small molecule with its target protein(s) inside living cells.

ISSN 

0002-7863

Link 

http://dx.doi.org/10.1021/ja303518d

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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