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Title 

Delivery of IL-12p40 ameliorates DSS-induced colitis by suppressing IL-17A expression and inflammation in the intestinal mucosa

Authors 

Doo Jin KimK S KimM Y SongS H SeoS J KimB G YangM H JangY C Sung

Publisher 

Elsevier

Issue Date 

2012

Citation 

Clinical Immunology, vol. 144, no. 3, pp. 190-199

Keywords 

DSS-induced colitisIL-12p40IL-17AInflammatory bowel disease (IBD)

Abstract 

IL-12p40 homodimer is a natural antagonist of IL-12 and IL-23, which are potent pro-inflammatory cytokines required for Th1 and Th17 immune responses, respectively. It has been reported that Th17 response is involved in inflammatory bowel disease (IBD), a chronic disorder of the digestive system with steadily increasing incidence. Here, we investigated the effects of IL-12p40 delivered via recombinant adenovirus (rAd/IL-12p40) or mesenchymal stem cells (MSC/IL-12p40) in a dextran sulfate sodium salt (DSS)-induced colitis model. Injection of rAd/IL-12p40 or MSC/IL-12p40 efficiently attenuated colitis symptoms and tissue damage, leading to an increased survival rate. Moreover, IL-12p40 delivery suppressed IL-17A, but enhanced IFN-γ production from mesenteric lymph node cells, supporting the preferential suppression of IL-23 by IL-12p40 homodimer in vitro and the suppression of Th17 responses in vivo. Our results demonstrate that IL-12p40 delivery ameliorates DSS-induced colitis by suppressing IL-17A production and inflammation in the intestinal mucosa, providing an effective new therapeutic strategy for IBDs.

ISSN 

1521-6616

Link 

http://dx.doi.org/10.1016/j.clim.2012.06.009

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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