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Title 

Anti-allergic effect of a chloroform-soluble extract of Cinnamomum cambodianum in bone marrow-derived mast cells

Authors 

Hee Sung ChaeP KhievHyeong Kyu LeeSei Ryang OhY W Chin

Publisher 

Informa Healthcare

Issue Date 

2012

Citation 

Immunopharmacology and Immunotoxicology, vol. 34, no. 4, pp. 639-644

Keywords 

Bone marrow-derived mast cellCinnamomum cambodianumDegranulationInterleukin-6Leukotriene C4Prostaglandin D2

Abstract 

Cinnamomum cambodianum has been used as a traditional medicine in Cambodia. Its effect on the bone marrow-derived mast cells (BMMCs) mediated allergic response remains unknown. In this study, a chloroform-soluble extract of C. cambodianum was evaluated for its effect on allergicmediators, including prostaglandin D2 (PGD2), leukotriene C4 (LTC4), β-hexosaminidase and cyclooxygenase-2 (COX-2) protein, in phorbol 12-myristate 13-acetate (PMA) plus calcimycin-stimulated BMMCs. The results revealed that the chloroform-soluble extractinhibited the production of interleukin-6, PGD2 and LTC4, and the expression of COX-2 in PMA plus calcimycin-stimulated BMMCs, implying a potential benefit of C. cambodianum in the treatment of allergy.

ISSN 

0892-3973

Link 

http://dx.doi.org/10.3109/08923973.2011.648267

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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