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Title | Anti-allergic effect of a chloroform-soluble extract of Cinnamomum cambodianum in bone marrow-derived mast cells |
Authors | Hee Sung Chae; P Khiev; Hyeong Kyu Lee; Sei Ryang Oh; Y W Chin |
Publisher | Informa Healthcare |
Issue Date | 2012 |
Citation | Immunopharmacology and Immunotoxicology, vol. 34, no. 4, pp. 639-644 |
Keywords | Bone marrow-derived mast cell; Cinnamomum cambodianum; Degranulation; Interleukin-6; Leukotriene C4; Prostaglandin D2 |
Abstract | Cinnamomum cambodianum has been used as a traditional medicine in Cambodia. Its effect on the bone marrow-derived mast cells (BMMCs) mediated allergic response remains unknown. In this study, a chloroform-soluble extract of C. cambodianum was evaluated for its effect on allergicmediators, including prostaglandin D2 (PGD2), leukotriene C4 (LTC4), β-hexosaminidase and cyclooxygenase-2 (COX-2) protein, in phorbol 12-myristate 13-acetate (PMA) plus calcimycin-stimulated BMMCs. The results revealed that the chloroform-soluble extractinhibited the production of interleukin-6, PGD2 and LTC4, and the expression of COX-2 in PMA plus calcimycin-stimulated BMMCs, implying a potential benefit of C. cambodianum in the treatment of allergy. |
ISSN | 0892-3973 |
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Registered Date |
2017-04-19 |
