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Title 

Inhibition of UVB-induced wrinkle formation and MMP-9 expression by mangiferin isolated from Anemarrhena asphodeloides

Authors 

Hui Seong KimJ H SongU J YounJ W HyunW S JeongM Y LeeH J ChoiHyeong Kyu LeeS Chae

Publisher 

Elsevier

Issue Date 

2012

Citation 

European Journal of Pharmacology, vol. 689, no. 1, pp. 38-44

Keywords 

MangiferinMMP-9 (Matrix metalloproteinase)Skin agingUltraviolet B

Abstract 

Chronic exposure of human skin to solar ultraviolet (UV) radiation causes photoaging. Naturally occurring phytochemicals are known to have anti-photoaging effects. The present study examined the effect of mangiferin isolated from Anemarrhena asphodeloides on wrinkle formation, skin thickness, and changes in collagen fibers in hairless mice. The in vitro effects and possible mechanism of mangiferin on UVB irradiation were determined in human keratinocyte (HEKa) cells. In vitro results showed that mangiferin reduced UVB-induced matrix metalloproteinase (MMP)-9 protein expression and enzyme activity and subsequent attenuation of UVB-induced phosphorylation of mitogen-activated protein kinase kinase1 (MEK) and extracellular signal-regulated kinase (ERK). In the in vivo studies, mangiferin inhibited UVB-induced mean length and mean depth of skin wrinkle based on skin replica, epidermal thickening, and damage to collagen fiber. Taken together, these results indicate that mangiferin exerts anti-photoaging activity in UVB-irradiated hairless mice by regulating MMP-9 expression through inhibition of MEK and ERK.

ISSN 

0014-2999

Link 

http://dx.doi.org/10.1016/j.ejphar.2012.05.050

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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