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Title 

Computational prediction of protein-protein interactions of human tyrosinase

Authors 

S F WangSangho OhY X SiZ J WangH Y HanJinhyuk LeeG Y Qian

Publisher 

SAGE-Hindawi Access to Research

Issue Date 

2012

Citation 

Enzyme Research, vol. 2012, no. 0, pp. 192867-192867

Abstract 

The various studies on tyrosinase have recently gained the attention of researchers due to their potential application values and the biological functions. In this study, we predicted the 3D structure of human tyrosinase and simulated the protein-protein interactions between tyrosinase and three binding partners, four and half LIM domains 2 (FHL2), cytochrome b-245 alpha polypeptide (CYBA), and RNA-binding motif protein 9 (RBM9). Our interaction simulations showed significant binding energy scores of -595.3 kcal/mol for FHL2, -859.1 kcal/mol for CYBA, and -821.3 kcal/mol for RBM9. We also investigated the residues of each protein facing toward the predicted site of interaction with tyrosinase. Our computational predictions will be useful for elucidating the protein-protein interactions of tyrosinase and studying its binding mechanisms.

ISSN 

2090-0406

Link 

http://dx.doi.org/10.1155/2012/192867

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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