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Title 

Anti-inflammatory and anti-allergic effect of Agaricus blazei extract in bone marrow-derived mast cells

Authors 

Hyuk Hwan SongHee Sung ChaeSei Ryang OhHyeong Kyu LeeY W Chin

Publisher 

World Scientific Publishing

Issue Date 

2012

Citation 

American Journal of Chinese Medicine, vol. 40, no. 5, pp. 1073-1084

Keywords 

Agaricus blazeiAktBone Marrow Derived Mast CellDegranulationInterleukin-6Leukotriene C 4Prostaglandin D 2

Abstract 

In this study, the anti-inflammatory and anti-allergic effects of the chloroform-soluble extract of Agaricus blazei in mouse bone marrow-derived mast cells (BMMCs) were investigated. The chloroform-soluble extract inhibited IL-6 production in PMA plus A23187-stimulated BMMCs, and down-regulated the phosphorylation of Akt. In addition, this extract demonstrated inhibition of the degranulation of β-hexosaminidase and the production of IL-6, prostaglandin D 2 and leukotriene C 4 in PMA plus A23187-induced BMMCs. In conclusion, the chloroform-soluble extract of Agaricus blazei exerted anti-inflammatory and anti-allergic activities mediated by influencing IL-6, prostaglandin D 2, leukotriene C 4, and the phosphorylation of Akt.

ISSN 

0192-415X

Link 

http://dx.doi.org/10.1142/S0192415X12500796

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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