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Title 

The biological effects of bovine lactoferrin on inflammatory cytokine expression in the PMA stimulated cells

 

PMA로 자극되어진 세포에서 염증 cytokine 발현에 미치는 bovine lactoferrin의 생물활성 영향

Authors 

S H ChungHo Bum KangJae Wha KimS S YoonM S Nam

Issue Date 

2012

Citation 

Korean Journal for Food Science of Animal Resources, vol. 32, no. 3, pp. 364-368

Keywords 

ovine lactoferrinimmune modulatorinflammatorybiological function

Abstract 

Bovine lactoferrin is well known as biological activator in defense mechanism related some cells. In this study, we was investigated about the immune modulator as a role of lactoferrin through the transcriptional regulation of genes associated with hypersensitivity such as allergy, athma and inflammatory disease. Effects of inflammatory reaction of bovine lactoferrin was carried out by RT-PCR analysis from isolated total RNA treated with lactoferrin 0, 10, 50, 100, 500 μg/mL and PMA 100 ng/mL. The expression of the TYROBP, PITPNA, IL-10, SLP1, DC-stamp and ICAM-1 mRNA were increased by synergy effect of bovine lactoferrin and PMA. The results of RT-PCR showed that bovine lactoferrin and PMA had an effect of immune modulator by enhancement of TYROBP, PITPNA, SLP1, DC-stamp, IL-10 and ICAM-1 gene transcription in U937, Mutz-3 and NK92 cells, respectively. Bovine lactoferrin showed a potential of biological function which could be used for industrial applications as a material of food and pharmaceutical.

ISSN 

1225-8563

Link 

http://dx.doi.org/10.5851/kosfa.2012.32.3.364

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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