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Title 

Cryptotanshinone and tanshinone IIA enhance IL-15-induced natural killer cell differentiation

Authors 

Won Sam KimDong Oh KimSung Jin YoonMi Jeong KimSuk Ran YoonYoung-Jun ParkHaiyoung JungTae-Don KimByoung-Mog KwonIn Pyo Choi

Publisher 

Elsevier

Issue Date 

2012

Citation 

Biochemical and Biophysical Research Communications, vol. 425, no. 2, pp. 340-347

Keywords 

CryptotanshinoneDifferentiationId2NK cellsTanshinone IIA

Abstract 

Natural killer (NK) cells are a subset of lymphocytes crucial for innate and adaptive immune responses. Here we show a stimulatory effect of cryptotanshinone (CTS) and tanshinone IIA (TS), isolated from Salvia miltiorrhiza Bunge, on the differentiation of NK cells. In the presence of IL-15, tanshinones increased NK cell maturation, NK cell differentiation and the expression of several transcription factors, including Id2, GATA3, T-bet, and Ets-1. Additionally, tanshinones increased p38 MAPK phosphorylation during NK cell differentiation. Furthermore, the p38 inhibitor SB203580 blocked the developmental effects of the tanshinones and suppressed Id2, T-bet, and Ets-1 expression during NK cell differentiation. These results suggest that tanshinones

ISSN 

0006-291X

Link 

http://dx.doi.org/10.1016/j.bbrc.2012.07.093

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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