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Title 

CDK2 differentially controls normal cell senescence and cancer cell proliferation upon exposure to reactive oxygen species

Authors 

Chae Young HwangSeung Min LeeSung Sup ParkKi Sun Kwon

Publisher 

Elsevier

Issue Date 

2012

Citation 

Biochemical and Biophysical Research Communications, vol. 425, no. 1, pp. 94-99

Keywords 

CDK2H 2O 2P21 Cip1PCNAProliferationSenescence

Abstract 

Reactive oxygen species modulate cell fate in a context-dependent manner. Sublethal doses of H 2O 2 decreased the level of proliferating cell nuclear antigen (PCNA) in normal cells (including primary human dermal fibroblasts and IMR-90 cells) without affecting cyclin-dependent kinase 2 (CDK2) activity, leading to cell cycle arrest and subsequent senescence. In contrast, exposure of cancer cells (such as HeLa and MCF7 cells) to H 2O 2 increased CDK2 activity with no accompanying change in the PCNA level, leading to cell proliferation. A CDK2 inhibitor, CVT-313, prevented H 2O 2-induced cancer cell proliferation. These results support the notion that the cyclin/CDK2/p21 Cip1/PCNA complex plays an important role as a regulator of cell fate decisions.

ISSN 

0006-291X

Link 

http://dx.doi.org/10.1016/j.bbrc.2012.07.059

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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