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Title 

Cycloartane-type triterpene glycosides from the rhizomes of Cimicifuga heracleifolia and their anticomplementary activity

Authors 

J H LeeT D CuongS J KwackJ H SeokJ K LeeJ Y JeongM H WooJ S ChoiHyeong Kyu LeeM S Min

Publisher 

Georg Thieme Verlag

Issue Date 

2012

Citation 

Planta Medica, vol. 78, no. 12, pp. 1391-1394

Keywords 

anticomplement activityCimicifuga heracleifoliacycloartane glycosideRanunculaceae

Abstract 

Seven known triterpene glycosides, 23-O-acetylshengmanol 3-O-α-L-arabinopyranoside (1), 23-O-acetylshengmanol 3-O-β-D- xylopyranoside (2), 24-epi-24-O-acetylhydroshengmanol 3-O-β-D- xylopyranoside (3), cimiaceroside B (4), (23R,24S)-cimigenol 3-O-β-D-xylopyranoside (5), (23R,24R)-25-O-acetylcimigenol 3-O-β-D-xylopyranoside (6) and (23R,24S)-25-O-anhydrocimigenol 3-O-β-D-xylopyranoside (7) were isolated from the rhizomes of Cimicifuga heracleifolia. Their chemical structures were determined on the basis of spectroscopic analyses including 2D NMR. All isolates were investigated for their inhibitory effects on the classical pathway of the complement system. Among them, compound 6 showed strong inhibitory activity with an ICvalue of 7.7 M while compound 3 was moderately active with an ICvalue of 195.6 M.

ISSN 

0032-0943

Link 

http://dx.doi.org/10.1055/s-0032-1314980

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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