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Title 

Recent trends in development of biosensors for detection of microcystin

Authors 

S SinghA SrivastavaHee-Mock OhChi-Yong AhnG G ChoiR K Asthana

Publisher 

Elsevier

Issue Date 

2012

Citation 

Toxicon, vol. 60, no. 5, pp. 878-894

Keywords 

Enzyme biosensorImmunosensorMicrocystinNucleic acid biosensor

Abstract 

Increased cyanobacterial blooms, a source of cyanotoxins are linked with climate change and eutrophication in aquatic bodies, a major concern worldwide. Microcystins are potently hepatotoxic, nephrotoxic as well as carcinogenic. Thus microcystins are threat to tourism, agriculture and animal's health. However, there is a still lacuna in the knowledge of regulation of microcystins production. Presence of toxic and non-toxic cyanobacterial strains together and occurrence of various microcystin variants in aquatic bodies compounded the problem. Although several analytical techniques for microcystin detection such as bioassay, ELISA, HPLC and LC-MS etc. have been already prevalent, the development of biosensors offered rapid and accurate detection, high reproducibility and portability. Sequencing of Microcystis spp., opened the new vistas towards the development of biosensor at molecular and genetic level. This review incorporates the current trends in the development of biosensors for microcystin detection in the light of state-of-the-art techniques.

ISSN 

0041-0101

Link 

http://dx.doi.org/10.1016/j.toxicon.2012.06.005

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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