상세 정보

underline
Metadata Downloads : dc(xml) or Excel
Cited 0 time in scopus ci

Title 

The role of heterodimeric AP-1 protein comprised of JunD and c-Fos proteins in hematopoiesis

Authors 

S Y LeeJ YoonM H LeeS K JungDong Joon KimA M BodeJ KimZ Dong

Publisher 

American Society for Biochemistry and Molecular Biology

Issue Date 

2012

Citation 

Journal of Biological Chemistry, vol. 287, no. 37, pp. 31342-31348

Abstract 

Activator protein-1 (AP-1) regulates a wide range of cellular processes including proliferation, differentiation, and apoptosis. As a transcription factor, AP-1 is commonly found as a heterodimer comprised of c-Jun and c-Fos proteins. However, other heterodimers may also be formed. The function of these dimers, specifically the heterodimeric AP-1 comprised of JunD and c-Fos (AP-1 JunD/c-Fos), has not been elucidated. Here, we identified a function of AP-1 JunD/c-Fos in Xenopus hematopoiesis. A gain-of-function study performed by overexpressing junD and c-fos and a loss-of-function study using morpholino junD demonstrate a critical role for AP-1 JunD/c-Fos in hematopoiesis during Xenopus embryogenesis. Additionally, we confirmed that JunD of AP-1 JunD/c-Fos is required for BMP-4-induced hematopoiesis. We also demonstrated that BMP-4 regulated JunD activity at the transcriptional regulation and post-translational modification levels. Collectively, our findings identify AP-1 JunD/c-Fos as a novel hematopoietic transcription factor and the requirement of AP-1 JunD/c-Fos in BMP-4-induced hematopoiesis during Xenopus hematopoiesis.

ISSN 

0021-9258

Link 

http://dx.doi.org/10.1074/jbc.M112.387266

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


There are no files associated with this item.
qrcode

FusionCharts.
DSpace Software Coptright(c) 2010 MIT and Hewleft-Packard  /  KRIBB-REPOSITORY ( Email:jakim@kribb.re.kr)