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Title 

Design, synthesis, and anti-influenza viral activities of 1,3-diarylprop-2-en-1-ones: a novel class of neuraminidase inhibitors

Authors 

M KingerY D ParkJ H ParkM G HurHyung Jae JungSu-Jin ParkWoo Song LeeS W KimS D Yang

Publisher 

Pharmaceutical Society of Korea

Issue Date 

2012

Citation 

Archives of Pharmacal Research, vol. 35, no. 4, pp. 633-638

Keywords 

1,3-Diarylprop-2-en-1-onesAnti-influenza activityNeuraminidaseSynthesis

Abstract 

A series of 1,3-diarylprop-2-en-1-one derivatives 3a-v have been synthesized and evaluated for their ability to inhibit neuraminidase (NA). Among the prepared compounds, the less lipophilic derivative 3k showed the most potent in vitro inhibitory activity against NA with an IC50 value of 1.5 μM.

ISSN 

0253-6269

Link 

http://dx.doi.org/10.1007/s12272-012-0406-2

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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