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Title 

Artemisinin inhibits lipopolysaccharide-induced interferon-beta production in RAW 264.7 cells: implications on signal transducer and activator of transcription-1 signaling and nitric oxide production

Authors 

Ki Hwan ParkYeo Dae YoonS B HanSoo Jin OhJieun YunChang Woo LeeK LeeS K ParkH M KimJong Soon Kang

Publisher 

Elsevier

Issue Date 

2012

Citation 

International Immunopharmacology, vol. 14, no. 3, pp. 580-584

Keywords 

ArtemisininIFN-βNitric oxideSTAT-1

Abstract 

Artemisinin is a well-known anti-malarial drug and has been shown to inhibit nitric oxide (NO) production. In this study, we investigated the effect of artemisinin on lipopolysaccharide (LPS)-induced production of IFN-β and characterized the potential relationship between artemisinin-mediated inhibition of IFN-β and NO production. Artemisinin suppressed IFN-β production and mRNA expression in a dose-dependent manner in LPS-stimulated RAW 264.7 cells. LPS-induced phosphorylation of signal transducer and activator of transcription-1 (STAT-1) was also inhibited by artemisinin treatment in RAW 264.7 cells. In addition, artemisinin suppressed LPS-induced production of NO in RAW 264.7 cells. Further study demonstrated that artemisinin-mediated inhibition of NO production and STAT-1 phosphorylation was reversed by addition of exogenous IFN-β. Moreover, artemisinin does not affect IFN-β-induced STAT-1 phosphorylation in RAW 264.7 cells. Collectively, these results suggest that the inhibition of IFN-β production by artemisinin and concomitant attenuation of STAT-1 activation might be involved in artemisinin-mediated inhibition of NO production in macrophages.

ISSN 

1567-5769

Link 

http://dx.doi.org/10.1016/j.intimp.2012.09.012

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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