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Title 

Beta-Lapachon, a modulator of NAD metabolism, prevents health declines in aged mice

Authors 

J S LeeA H ParkS H LeeJ H KimSuk Jin YangYoung Il YeomT H KwakD LeeS J LeeChul Ho LeeJ M KimD Kim

Publisher 

Public Library of Science

Issue Date 

2012

Citation 

Plos One, vol. 7, no. 10, pp. e47122-e47122

Abstract 

NADH-quinone oxidoreductase 1 (NQO1) modulates cellular NAD +/NADH ratio which has been associated with the aging and anti-aging mechanisms of calorie restriction (CR). Here, we demonstrate that the facilitation of NQO1 activity by feeding β-lapachone (βL), an exogenous NQO1 co-substrate, prevented age-dependent decline of motor and cognitive function in aged mice. βL-fed mice did not alter their food-intake or locomotor activity but did increase their energy expenditure as measured by oxygen consumption and heat generation. Mitochondrial structure and numbers were disorganized and decreased in the muscles of control diet group but those defects were less severe in βL-fed aged mice. Furthermore, for a subset of genes associated with energy metabolism, mice fed the βL-diet showed similar changes in gene expression to the CR group (fed 70% of the control diet). These results support the potentiation of NQO1 activity by a βL diet and could be an option for preventing age-related decline of muscle and brain functions.

ISSN 

1932-6203

Link 

http://dx.doi.org/10.1371/journal.pone.0047122

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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