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Title 

Direct lineage reprogramming to neural cells

 

신경계 세포로의 직접적인 계통 리프로그래밍(교차분화)

Authors 

Janghwan KimR AmbasudhanS Ding

Publisher 

Elsevier

Issue Date 

2012

Citation 

Current Opinion in Neurobiology, vol. 22, no. 5, pp. 778-784

Abstract 

Recently we have witnessed an array of studies on direct reprogramming that describe induced inter conversion of mature cell types from higher organisms including human. While these studies reveal an unexpected level of plasticity of differentiated somatic cells, they also provide unprecedented opportunities to develop regenerative therapies for many debilitating disorders and model these 'diseases-in-a-dish' for studying their pathophysiology. Here we review the current state of the art in direct lineage reprogramming to neural cells, and discuss the challenges that need to be addressed toward achieving the full potential of this exciting new technology.

ISSN 

0959-4388

Link 

http://dx.doi.org/10.1016/j.conb.2012.05.001

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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