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Title 

Peroxiredoxin I deficiency attenuates phagocytic capacity of macrophage in clearance of the red blood cells damaged by oxidative stress

Authors 

Y H HanTaeho KwonSun-Uk KimH L HaT H LeeJ M KimE K JoBo Yeon KimD Y YoonDae Yeul Yu

Publisher 

Korean Society for Biochemistry and Molecular Biology

Issue Date 

2012

Citation 

BMB Reports, vol. 45, no. 10, pp. 560-564

Keywords 

Heinz bodyHemolytic anemiaMacrophagePeroxiredoxinPhagocytosis

Abstract 

The role of peroxiredoxin (Prx) I as an erythrocyte antioxidant defense in red blood cells (RBCs) is controversial. Here we investigated the function of Prx I by using Prx I-/- and Prx I/II-/- mice. Prx I-/- mice exhibited a normal blood profile. However, Prx I/II-/- mice showed more significantly increased Heinz body formation as compared with Prx II-/- mice. The clearance rate of Heinz body-containing RBCs in Prx I-/- mice decreased significantly through the treatment of aniline hydrochloride (AH) compared with wild-type mice. Prx I deficiency decreased the phagocytic capacity of macrophage in clearing Heinz bodycontaining RBCs. Our data demonstrate that Prx I deficiency did not cause hemolytic anemia, but showed that furtherincreased hemolytic anemia symptoms in Prx II-/- mice by attenuating phagocytic capacity of macrophage in oxidative stress damaged RBCs, suggesting a novel role of Prx I in phagocytosis of macrophage.

ISSN 

1976-6696

Link 

http://dx.doi.org/10.5483/BMBRep.2012.45.10.082

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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