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Title 

Orphan nuclear receptor small heterodimer partner negatively regulates growth hormone-mediated induction of hepatic gluconeogenesis through inhibition of signal transducer and activator of transcription 5 (STAT5) transactivation

Authors 

Y D KimT LiS W AhnD K KimJ M LeeS L HwangYong Hoon KimChul Ho LeeI K LeeJ Y L CiangH S Choi

Publisher 

American Society for Biochemistry and Molecular Biology

Issue Date 

2012

Citation 

Journal of Biological Chemistry, vol. 287, no. 44, pp. 37098-37108

Abstract 

Background: Growth hormone (GH) is involved in hepatic glucose metabolism. Results: GH increased hepatic gluconeogenesis through STAT5 transactivation, which was abolished by the metformin-ATMAMPK-SHP pathway. Conclusion: The metformin-ATM-AMPK-SHP network prevents the increase of hepatic gluconeogenesis by the GH-dependent pathway. Significance: The ATM-AMPK-SHP pathway may provide a novel mechanism for regulating hepatic glucose homeostasis via a GH-dependent pathway.

ISSN 

0021-9258

Link 

http://dx.doi.org/10.1074/jbc.M112.339887

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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