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Title 

Activation of cannabinoid receptor type 1 (Cb1r) disrupts hepatic insulin receptor signaling via cyclic AMP-response element-binding protein H (Crebh)-mediated induction of Lipin1 gene

Authors 

D ChandaYong Hoon KimD K KimM W LeeS Y LeeT S ParkS H KooChul Ho LeeH S Choi

Publisher 

American Society for Biochemistry and Molecular Biology

Issue Date 

2012

Citation 

Journal of Biological Chemistry, vol. 287, no. 45, pp. 38041-38049

Abstract 

Background: The role of Cb1r signaling-mediated activation of Crebh in regulating lipid metabolism and insulin signaling is currently unknown. Results: Cb1r signaling regulates Lipin1 gene transcription via Crebh and inhibits insulin receptor signaling. Conclusion: Crebh-mediated activation of Lipin1 by Cb1r deregulates insulin receptor signaling. Significance: Relieving higher hepatic DAG levels by targeting its upstream regulators might be beneficial to restore insulin signaling.

ISSN 

0021-9258

Link 

http://dx.doi.org/10.1074/jbc.M112.377978

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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