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Title 

Development and validation of a prognostic gene-expression signature for lung adenocarcinoma

Authors 

Y Y ParkE S ParkS B KimSang Cheol KimB H SohnIn-Sun ChuW JeongG B MillsL A ByersJ S Lee

Publisher 

Public Library of Science

Issue Date 

2012

Citation 

Plos One, vol. 7, no. 9, pp. e44225-e44225

Abstract 

Although several prognostic signatures have been developed in lung cancer, their application in clinical practice has been limited because they have not been validated in multiple independent data sets. Moreover, the lack of common genes between the signatures makes it difficult to know what biological process may be reflected or measured by the signature. By using classical data exploration approach with gene expression data from patients with lung adenocarcinoma (n = 186), we uncovered two distinct subgroups of lung adenocarcinoma and identified prognostic 193-gene gene expression signature associated with two subgroups. The signature was validated in 4 independent lung adenocarcinoma cohorts, including 556 patients. In multivariate analysis, the signature was an independent predictor of overall survival (hazard ratio, 2.4; 95% confidence interval, 1.2 to 4.8; p = 0.01). An integrated analysis of the signature revealed that E2F1 plays key roles in regulating genes in the signature. Subset analysis demonstrated that the gene signature could identify high-risk patients in early stage (stage I disease), and patients who would have benefit of adjuvant chemotherapy. Thus, our study provided evidence for molecular basis of clinically relevant two distinct two subtypes of lung adenocarcinoma.

ISSN 

1932-6203

Link 

http://dx.doi.org/10.1371/journal.pone.0044225

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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