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Title 

Inhibition of LFA-1/ICAM-1-mediated cell adhesion by stilbene derivatives from Rheum undulatum

 

스틸벤 유도체에 의한 LFA-1/ICAM-1-매개 세포부착 억제 효능

Authors 

Seung Woong LeeB S HwangMi-Hwa KimChan Sun ParkWoo Song LeeHyun Mee OhMun Chual Rho

Publisher 

Pharmaceutical Society of Korea

Issue Date 

2012

Citation 

Archives of Pharmacal Research, vol. 35, no. 10, pp. 1763-1770

Keywords 

Anti-inflammatory agentsCell adhesion moleculesIntercellular adhesion molecule-1 (ICAM-1)Lymphocyte function-associated antigen-1 (LFA-1)Rheum undulatumStilbenes

Abstract 

Six stilbenes were isolated from the methanol extract of Rheum undulatum rhizomes by bioactivity- guided fractionation. The structures of the compounds were determined by spectroscopic analysis (1H-, 13C-NMR and MS), to be desoxyrhapontigenin (1), rhapontigenin (2), trans-resveratrol (3), piceatannol (4), piceatannol-3'-O-β-D-glucopyranoside (5) and isorhapontin (6). Compounds 1-4 inhibited the direct binding between sICAM-1 and LFA-1 of the THP- 1 cells in a dose-dependent manner with IC50 values of 50.1, 25.4, 33.4 and 45.9 μM, respectively. On the other hand, the other compounds 5 and 6 with a glucose moiety in each molecule did not show any inhibitory activity in the cell adhesion assay (IC50 values of >100.0 μM). Compounds 2, 3 and 4 also had an inhibitory effect on direct binding between sVCAM-1 and VLA-4 of THP-1 cells. This suggests that the stilbenes from Rheum undulatum rhizomes are good candidates for therapeutic strategies towards inflammation.

ISSN 

0253-6269

Link 

http://dx.doi.org/10.1007/s12272-012-1008-8

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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