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Title 

Anti-human rhinoviral activity of polybromocatechol compounds isolated from the rhodophyta, Neorhodomela aculeate

Authors 

S H ParkJ H SongT KimW S ShinG M ParkS LeeY J KimP ChoiH KimHui Seong KimDur Han KwonH J ChoiJ Ham

Publisher 

MDPI

Issue Date 

2012

Citation 

Marine Drugs, vol. 10, no. 10, pp. 2222-2233

Keywords 

Antiviral activityHuman rhinovirusNeorhodomela aculeatePolybromocatechol compoundsRed alga

Abstract 

An extract of the red alga, Neorhodomela aculeata, exhibited antiviral activity against human rhinoviruses. Bioassay-guided purification was performed to yield six compounds, which were subsequently identified as lanosol (1) and five polybromocatechols (2-6) by spectroscopic methods, including 1D and 2D NMR and mass spectrometric analyses. Structurally, all of these compounds, except compound 5, contain one or two 2,3-dibromo-4,5-dihydroxyphenyl moieties. In a biological activity assay, compound 1 was found to possess antiviral activity with a 50% inhibitory concentration (IC 50) of 2.50 μg/mL against HRV2. Compound 3 showed anti-HRV2 activity, with an IC 50 of 7.11 μg/mL, and anti-HRV3 activity, with an IC 50 of 4.69 μg/mL, without demonstrable cytotoxicity at a concentration of 20 μg/mL. Collectively, the results suggest that compounds 1 and 3 are candidates for novel therapeutics against two different groups of human rhinovirus.

ISSN 

1660-3397

Link 

http://dx.doi.org/10.3390/md10102222

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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