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Title 

Protective effects of pine bark extract on developmental toxicity of cyclophosphamide in rats

Authors 

S H KimI C LeeJ H LimC MoonC S BaeD H ShinS C ParkHyoung-Chin KimJ C Kim

Publisher 

Elsevier

Issue Date 

2012

Citation 

Food and Chemical Toxicology, vol. 50, no. 2, pp. 109-115

Keywords 

CyclophosphamideDevelopmental toxicityOxidative stressProtective effectsPycnogenol®

Abstract 

This study investigated the protective effects of pine bark extract (Pycnogenol®, PYC) against cyclophosphamide (CP)-induced developmental toxicity in rats. A total of 44 mated females were randomly assigned to the following four experimental groups: (1) vehicle control, (2) CP, (3) CP&PYC, or (4) PYC. All dams were subjected to a Caesarean section on day 20 of gestation, and fetuses were examined for morphological abnormalities. Oxidative stress analysis was performed on maternal hepatic tissues. CP treatment caused decreased fetal and placental weights and increased embryonic resorptions and fetal malformations. In addition, an increased malondialdehyde (MDA) concentration and decreased reduced glutathione (GSH) content and catalase activity were observed in the hepatic tissues. On the contrary, PYC treatment during pregnancy significantly ameliorated the CP-induced embryo-fetal developmental toxicity in rats. Moreover, MDA and GSH concentrations and catalase activity in hepatic tissues were not affected when PYC was administered in conjunction with CP. These results suggest that repeated administration of PYC has beneficial effects against CP-induced embryo-fetal developmental toxicity in rats, and that the protective effects of PYC may be due to both inhibition of lipid peroxidation and increased antioxidant activity.

ISSN 

0278-6915

Link 

http://dx.doi.org/10.1016/j.fct.2011.10.048

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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