상세 정보

underline
Metadata Downloads : dc(xml) or Excel
Cited 0 time in scopus ci

Title 

Analyses of pig genomes provide insight into porcine demography and evolution

Authors 

M A M GroenenA L ArchibaldH UenishiC K TuggleY TakeuchiM F RothschildC Rogel-GaillardC ParkD MilanH J MegensS LiD M LarkinH KimL A F FrantzM CaccamoH AhnB L AkenA AnselmoC AnthonL AuvilSang-Haeng ChoiHong-Seog ParkL B Schook

Publisher 

Nature Publishing Group

Issue Date 

2012

Citation 

Nature, vol. 491, no. 7424, pp. 393-398

Abstract 

For 10,000a €‰years pigs and humans have shared a close and complex relationship. From domestication to modern breeding practices, humans have shaped the genomes of domestic pigs. Here we present the assembly and analysis of the genome sequence of a female domestic Duroc pig (Sus scrofa) and a comparison with the genomes of wild and domestic pigs from Europe and Asia. Wild pigs emerged in South East Asia and subsequently spread across Eurasia. Our results reveal a deep phylogenetic split between European and Asian wild boars ∼1 million years ago, and a selective sweep analysis indicates selection on genes involved in RNA processing and regulation. Genes associated with immune response and olfaction exhibit fast evolution. Pigs have the largest repertoire of functional olfactory receptor genes, reflecting the importance of smell in this scavenging animal. The pig genome sequence provides an important resource for further improvements of this important livestock species, and our identification of many putative disease-causing variants extends the potential of the pig as a biomedical model.

ISSN 

0028-0836

Link 

http://dx.doi.org/10.1038/nature11622

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


There are no files associated with this item.
qrcode

FusionCharts.
DSpace Software Coptright(c) 2010 MIT and Hewleft-Packard  /  KRIBB-REPOSITORY ( Email:jakim@kribb.re.kr)