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Title 

Mangosteen xanthones mitigate ovalbumin-induced airway inflammation in a mouse model of asthma

 

망고스틴의 항천식효과

Authors 

Ha Young JangOk-Kyoung KwonSei Ryang OhHyeong Kyu LeeKyung Seop AhnY W Chin

Publisher 

Elsevier

Issue Date 

2012

Citation 

Food and Chemical Toxicology, vol. 50, no. 11, pp. 4042-4050

Keywords 

α-Mangostinγ-MangostinAsthmaGarcinia mangostana

Abstract 

α- and γ-Mangostin, which are the major xanthones purified from a Mangosteen, Garcinia mangostana Linn., exhibit a wide range of anticancer, antioxidant, and anti-inflammatory activities. Here, we assessed their therapeutic effects in a mouse model of ovalbumin (OVA)-induced allergic asthma. Animals were treated with α- and γ-mangostins orally for 3. days at doses of 10 and 30. mg/kg daily, 1. h before the OVA challenge. Administration of α- and γ-mangostins significantly reduced the major pathophysiological features of allergic asthma, including inflammatory cell recruitment into the airway, airway hyperresponsiveness (AHR), and increased levels of Th2 cytokines. In addition, α- and γ-mangostins attenuated the increases in phosphoinositide 3-kinase (PI3K) activity, phosphorylation of Akt, and NF-κB in nuclear protein extracts after OVA challenge. In conclusion, α- and γ-mangostin may have therapeutic potential for the treatment of allergic asthma.

ISSN 

0278-6915

Link 

http://dx.doi.org/10.1016/j.fct.2012.08.037

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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