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Title 

Ceftriaxone, an FDA-approved cephalosporin antibiotic, suppresses lung cancer growth by targeting Aurora B

Authors 

X LiH LiS LiF ZhuDong Joon KimH XieY LiJ NadasN OiT A ZykovaD H YuM H LeeM O KimL WangW MaR A LubetA M BodeZ Dong

Publisher 

Oxford University Press (OUP)

Issue Date 

2012

Citation 

Carcinogenesis, vol. 33, no. 12, pp. 2548-2557

Abstract 

Ceftriaxone, an FDA-approved third-generation cephalosporin antibiotic, has antimicrobial activity against both gram-positive and gram-negative organisms. Generally, ceftriaxone is used for a variety of infections such as community-acquired pneumonia, meningitis and gonorrhea. Its primary molecular targets are the penicillin-binding proteins. However, other activities of ceftriaxone remain unknown. Herein, we report for the first time that ceftriaxone has antitumor activity in vitro and in vivo. Kinase profiling results predicted that Aurora B might be a potential 'off' target of ceftriaxone. Pull-down assay data confirmed that ceftriaxone could bind with Aurora B in vitro and in A549 cells. Furthermore, ceftriaxone (500 μM) suppressed anchorage-independent cell growth by targeting Aurora B in A549, H520 and H1650 lung cancer cells. Importantly, in vivo xenograft animal model results showed that ceftriaxone effectively suppressed A549 and H520 lung tumor growth by inhibiting Aurora B. These data suggest the anticancer efficacy of ceftriaxone for the treatment of lung cancers through its inhibition of Aurora B.

ISSN 

0143-3334

Link 

http://dx.doi.org/10.1093/carcin/bgs283

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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